16 days in Europe Itinerary

Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.

To find maps, photos, reviews, and more tourist information, read our Rome online vacation planner.

Naples to Rome is an approximately 2-hour train ride. You can also drive; or fly. In April, daily temperatures in Rome can reach 24°C, while at night they dip to 11°C. On the 10th (Mon), you're off to Vatican City.

Covering 44 hectares (110 acres) in the city center of Rome, the wall-enclosed sovereign state of Vatican City is one of the most famous religious sites worldwide, serving as the papal residence and home of the Roman Catholic church.

On the 10th (Mon), pause for some photo ops at La Pieta, then admire the masterpieces at Vatican Museums, then admire the striking features of Cupola di San Pietro, and finally contemplate the long history of St. Peter's Basilica.

To see ratings, where to stay, more things to do, and more tourist information, read Vatican City online route maker.

Vatican City is just a stone's throw from Rome. In April, plan for daily highs up to 24°C, and evening lows to 11°C. Finish your sightseeing early on the 11th (Tue) to allow enough time to travel to Florence.

Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.

Kick off your visit on the 11th (Tue): get to know the fascinating history of Piazza della Signoria, contemplate in the serene atmosphere at The Baptistery of St. John, then appreciate the extensive heritage of Piazza del Duomo, then take in the spiritual surroundings of Cathedral of Santa Maria del Fiore, and finally enjoy breathtaking views from Campanile di Giotto. Get ready for a full day of sightseeing on the next day: take in the views from Ponte Vecchio, don't miss a visit to Piazzale Michelangelo, admire the natural beauty at The Boboli Gardens, then take in the architecture and atmosphere at Basilica of Santa Croce, and finally explore the world behind art at Florence Academy of Fine Arts.

To see other places to visit, where to stay, maps, and tourist information, read Florence planning site.

Getting from Vatican City to Florence by combination of bus and train takes about 2.5 hours. Other options: take a train; or drive. In April, daytime highs in Florence are 22°C, while nighttime lows are 11°C. Cap off your sightseeing on the 12th (Wed) early enough to go by car to Venice.

Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.

For other places to visit, ratings, maps, and tourist information, go to the Venice online road trip planner.

You can drive from Florence to Venice in 3 hours. Other options are to take a train; or take a bus. Expect a daytime high around 21°C in April, and nighttime lows around 11°C. You'll set off for Paris on the 13th (Thu).

A beautiful and romantic city fit for any itinerary, Paris brims with historic associations and remains vastly influential in the realms of culture, art, fashion, food and design.

Start off your visit on the 13th (Thu): admire the landmark architecture of Sainte-Chapelle, admire the masterpieces at Louvre Museum, and then pause for some serene contemplation at Basilique du Sacre-Coeur de Montmartre. Get ready for a full day of sightseeing on the next day: wander the streets of Île de la Cité, contemplate the long history of Eiffel Tower, then appreciate the history behind Arc de Triomphe, and finally explore the world behind art at Musee d'Orsay.

To find traveler tips, ratings, photos, and tourist information, you can read our Paris road trip planning app.

You can fly from Venice to Paris in 5 hours. Alternatively, you can take a train; or drive. Prepare for slightly colder weather when traveling from Venice in April: high temperatures in Paris hover around 18°C and lows are around 6°C. Wrap up your sightseeing by early afternoon on the 15th (Sat) to allow time for the train ride to Brussels.

The allure of the multi-cultural capital, Brussels, stems from its mix of political intrigue, artistic influence, historical significance, and a thriving social scene.

Kick off your visit on the 15th (Sat): pause for some photo ops at Manneken Pis, then contemplate the long history of Grand Place, and then see the interesting displays at Museum of Cocoa and Chocolate (Musee du Cacao et du Chocolat).

To see ratings, other places to visit, and more tourist information, use the Brussels journey planning app.

You can take a train from Paris to Brussels in 2.5 hours. Alternatively, you can fly; or drive. When traveling from Paris in April, plan for little chillier days and about the same nights in Brussels: temperatures range from 15°C by day to 4°C at night. Wrap up your sightseeing on the 17th (Mon) to allow time to drive to Amsterdam.

Known as one of the greatest small cities in the world, Amsterdam charms visitors with its cool and cozy atmosphere.

Get out of town with these interesting Amsterdam side-trips: Lisse (The Flower Bulb Region & Keukenhof). There's much more to do: explore the world behind art at Van Gogh Museum, explore the galleries of Museum Het Rembrandthuis, visit The Jordaan, and appreciate the extensive heritage of Begijnhof.

To find other places to visit, more things to do, maps, and tourist information, go to the Amsterdam trip planner.

Traveling by car from Brussels to Amsterdam takes 2.5 hours. Alternatively, you can take a train; or fly. In April in Amsterdam, expect temperatures between 15°C during the day and 5°C at night. Finish your sightseeing early on the 19th (Wed) so you can fly to Berlin.

The country's capital and largest city, Berlin is a diverse urban center boasting a lively nightlife and countless things to do.

Start off your visit on the 20th (Thu): make a trip to Brandenburg Gate, then pause for some photo ops at The Holocaust Memorial - Memorial to the Murdered Jews of Europe, and then admire the landmark architecture of Reichstag Building.

For traveler tips, ratings, maps, and tourist information, read our Berlin trip planner.

Fly from Amsterdam to Berlin in 4.5 hours. Alternatively, you can drive; or take a train. Cap off your sightseeing on the 20th (Thu) early enough to go by car to Prague.

Prague lures millions of tourists each year with its World Heritage-listed medieval city center--a labyrinth of narrow lanes, bridges, cathedrals, and palaces overlooked by a thousand-year-old castle.

On the 24th (Mon), spend a fun day on foot with Walking tours. There's lots more to do: take in the views from Charles Bridge, admire nature's wide array of creatures at Prague Zoo, admire the landmark architecture of Prague Astronomical Clock, and contemplate in the serene atmosphere at St. Vitus Cathedral.

To find other places to visit, maps, and other tourist information, read our Prague online trip itinerary maker.

Traveling by car from Berlin to Prague takes 3.5 hours. Alternatively, you can take a shuttle; or take a bus. In April, plan for daily highs up to 17°C, and evening lows to 5°C. Finish your sightseeing early on the 24th (Mon) so you can fly back home.